Linking database to website or flash application

Hi everyone, i was not sure where to post this. ill explain my problem and if there is a particular place for me to post this please let me know and ill post it there.

OK basically i am at uni in my final year and i have project and all i want is to learn how to link up a database full of questions and answers to a website.

i will be creating a treasure hunt game which the users will interact with but what i need is that if one question is answered, i want that question deleted off the database so that a new question can replace the answered question.

don't know if that made sense lol

i want to know what database software i should use to link it and also i might use a flash animated app rather then website does anyone know how to link that up to

thank you